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Association details:
| Biomarker: | PBRM1 mutation + TMB-H |
|---|---|
| Cancer: | Non Small Cell Lung Cancer |
| Drug Class: | Immunotherapy |
| Direction: | Resistant |
Evidence:
Source:
Title:
Non‑small cell lung cancer carrying PBRM1 mutation suggests an immunologically cold phenotype leading to immunotherapy failure even with high TMB
Published date:
12/01/2022
Excerpt:
In this study, we aimed to identify gene mutations associated with immunotherapy resistance and further informed mechanisms in NSCLC….Moreover, compared with PBRM1-WT/TMB-H group, OS was worse in the PBRM1-MT/TMB-H group.
DOI:
https://doi.org/10.1038/s41598-022-25050-3
