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Association details:
| Biomarker: | PAX2 promoter methylation |
|---|---|
| Cancer: | Breast Cancer |
| Drug: | tamoxifen (Estrogen receptor antagonist) |
| Direction: | Resistant |
Evidence:
Source:
Title:
PAX2 promoter methylation and AIB1 overexpression promote tamoxifen resistance in breast carcinoma patients
Published date:
01/28/2021
Excerpt:
Aberrant promoter methylation of PAX2 and overexpression of AIB1 was observed in tamoxifen resistance patients compared to the sensitive ones….Our results revealed that the aberration in PAX2 promoter methylation and AIB1 overexpression are associated with the tamoxifen response in breast carcinoma patients.
DOI:
10.1177/1078155221989404