...we evaluated apoptosis via both TUNEL and apoptotic marker (c-PARP and Bax) immunoreactivity in various groups....The immunohistochemical staining results showed that the c-PARP and Bax levels were increased in the treatment groups compared with the control group, and the anlotinib combined with chemoradiation-treated group exhibited the highest levels...Furthermore, anlotinib can exert antitumor effects via its antiangiogenic activity...