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    Association details:
    Biomarker:PAPSS1 underexpression
    Cancer:Lung Adenocarcinoma
    Drug:cisplatin (DNA synthesis inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    AACR 2017
    Title:

    In Vivo Validation of PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1) as a Cisplatin-sensitizing Therapeutic Target

    Excerpt:
    Low PAPSS1 expression is associated with higher sensitivity to cisplatin in lung adenocarcinoma cell lines...all 52 cell lines demonstrated that low PAPSS1 expression is significantly correlated with increased sensitivity to cisplatin...Low PAPSS1 expression is associated with sensitivity to cisplatin in lung adenocarcinoma cell lines.
    DOI:
    10.1158/1078-0432.CCR-17-0700