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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
Title:

2767 The Expression of Paks and Its Clinical Significance in T-Cell Lymphoblastic Lymphoma

Published date:
11/04/2020
Excerpt:
Patients with high PAK1 and PAK2 expression had significantly shorter median RFS than those with low PAK1 and PAK2 expression...The PAK inhibitors PF and FRAX597 demonstrated strong anti-tumor activity in vitro (Table 2). Both inhibitors suppressed cell proliferation in a time- and dose-dependent manner (Figure 5)....PAK1 and PAK2 play certain roles in the occurrence and recurrence of T-LBL, and their potential as novel biomarkers deserves further exploring. Our results underscore the potential of PAK inhibitor as effective target therapy for T-LBL.