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Association details:
| Biomarker: | P2RY8-CRLF2 fusion |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | Yervoy (ipilimumab) (CTLA4 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
P2RY8-CRLF2 Fusion–Positive Acute Myeloid Leukemia With Myelodysplasia-Related ChangesResponse to Novel Therapy
Excerpt:
Total RNA sequencing of the AML bone marrow specimen further confirmed the presence of the P2RY8-CRLF2 fusion...He was consented and enrolled in a study regimen consisting of standard-dose decitabine plus...ipilimumab...After 2 cycles of combination therapy, he achieved complete remission with incomplete count recovery and shortly thereafter a full complete remission...
Secondary therapy:
decitabine
DOI:
10.1200/PO.19.00294
