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Association details:
| Biomarker: | OGT underexpression |
|---|---|
| Cancer: | Ovarian Cancer |
| Drug: | cisplatin (DNA synthesis inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Down-regulation of OGT promotes cisplatin resistance by inducing autophagy in ovarian cancer
Excerpt:
The down-regulation of OGT increased cisplatin resistance in ovarian cancer cells but had no effect on the efficacy of paclitaxel. The down-regulation of OGT improved tumor resistance to cisplatin in a mouse xenograft tumor model.
DOI:
10.7150/thno.27806