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Association details:
| Biomarker: | NUP98-NSD1 fusion |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | VTP-50469 (Menin-MLL inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
The Menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML
Published date:
09/28/2021
Excerpt:
In addition to these in vitro studies, we established patient-derived xenograft (PDX) models of NUP98-fusion driven AML to test the in vivo efficacy of Menin-MLL1 inhibition. Treatment with VTP50469 significantly prolongs survival of mice engrafted with NUP98-NSD1 and NUP98-JARID1A leukemias.
DOI:
10.1182/blood.2021012806
