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Association details:
| Biomarker: | NUP98-NSD1 fusion + FLT3-ITD mutation |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | mitoxantrone (Topoisomerase II inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
The NUP98-NSD1 fusion gene in acute myeloid leukemia
Excerpt:
Furthermore, we discovered that NUP98-NSD1+/FLT3-ITD+ BM MNCs are highly resistant to topoisomerase II inhibitors such as mitoxantrone.
