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    Association details:
    Biomarker:NUP98-NSD1 fusion + FLT3-ITD mutation
    Cancer:Acute Myelogenous Leukemia
    Drug:mitoxantrone (Topoisomerase II inhibitor)
    Direction:Resistant
    Evidence:
    Evidence Level:
    Resistant: D – Preclinical
    New
    Source:
    Helda
    Title:

    The NUP98-NSD1 fusion gene in acute myeloid leukemia

    Excerpt:
    Furthermore, we discovered that NUP98-NSD1+/FLT3-ITD+ BM MNCs are highly resistant to topoisomerase II inhibitors such as mitoxantrone.