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Association details:
| Biomarker: | NUP98-KDM5A fusion |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug Class: | T-lymphocyte cell therapy |
| Direction: | Sensitive |
Evidence:
Source:
Title:
1531: Developing Immunocompetent Models to Evaluate B7-H3-CAR T Cells for Acute Myeloid Leukemia
Published date:
05/02/2023
Excerpt:
To test in vivo antitumor activity, mice were engrafted with 1e6 NUP98:KDM5A cells. A single of infusion of 3e6 mB7-H3-CAR T cells demonstrated significant anti-AML activity (p<0.001) when compared to control-CAR T cells, resulting in a survival advantage (p<0.01, N=5/group)....We demonstrate that mB7-H3-CAR T cells have potent anti-AML activity in vitro and in vivo.
