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Association details:
| Biomarker: | NTRK1 G667C |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | Rozlytrek (entrectinib) (ALK inhibitor, TrkB receptor inhibitor, TrkC kinase inhibitor, TrkA receptor inhibitor, ROS1 inhibitor, JAK2 inhibitor, TNK2 inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Acquired Resistance to the TRK Inhibitor Entrectinib in Colorectal Cancer
Excerpt:
Profiling of ctDNA at entrectinib resistance revealed two novel NTRK1 genetic alterations in the kinase domain of the protein, p.G595R and p.G667C, which were not detected in ctDNA obtained before initiation of therapy.
DOI:
10.1158/2159-8290.CD-15-0940
