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Association details:
Evidence:
Evidence Level:
Sensitive: A2 - Guideline
New
Source:
Excerpt:
Colon Cancer...SYSTEMIC THERAPY FOR ADVANCED OR METASTATIC DISEASE - CHEMOTHERAPY REGIMENS...Larotrectinib (NTRK gene fusion positive)
Evidence Level:
Sensitive: C1 - Off-label
  (Approved for Sarcoma)
New
Title:

New sarcoma drug approved for use in England

Excerpt:
We’re delighted to announce that a new drug, larotrectinib, has been approved for the treatment of certain sarcomas in England. ‘Sarcoma UK welcomes today’s approval of larotrectinib. Made available for use by the Cancer Drugs Fund and approved by NICE (National Institute for Health and Care Excellence) larotrectinib is a new type of ‘histologically-independent’ drug that targets tumours based on their genetic makeup. It works by targeting the specific NTKR genetic abnormality in tumours meaning patients are treated according to the genetics of their tumour rather than where it is in the body.
Evidence Level:
Sensitive: C3 – Early Trials
Source:
Title:

151 - Activity and safety of larotrectinib in adult patients with TRK fusion cancer: an expanded data set

Published date:
09/03/2020
Excerpt:
Adults (aged ≥18 y) with TRK fusion cancer treated in three larotrectinib clinical trials (NCT02122913, NCT02576431, and NCT02637687) were analyzed….Tumor types included thyroid cancer (22%), salivary gland cancer (19%), soft tissue sarcoma (16%), lung cancer (12%), colon cancer (7%), melanoma (5%), breast cancer (5%), GIST (3%), and 9 other types (≤2% each). TRK fusions involved NTRK1 (43%), NTRK2 (3%), and NTRK3 (54%)...The ORR was 71% (95% CI 62-79): 10% complete response, 60% partial response (2% pending confirmation), 16% stable disease, 9% progressive disease, 3% not determined.
Evidence Level:
Sensitive: C3 – Early Trials
Source:
Title:

150 - Efficacy and safety of larotrectinib in patients with TRK fusion gastrointestinal cancer

Published date:
09/03/2020
Excerpt:
Patients with a TRK fusion GI cancer treated with larotrectinib in a phase II clinical trial, NAVIGATE (NCT02576431), were included in this analysis….Fusions involved NTRK1 (n=12) and NTRK3 (n=2)...Overall best responses on larotrectinib were: colon cancer, 4 patients had a PR and 4 had stable disease (SD); pancreatic cancer, 1 patient had a PR and 1 had SD; cholangiocarcinoma, 1 patient had a PR and 1 had progressive disease...
Evidence Level:
Sensitive: C3 – Early Trials
Source:
Title:

Activity and safety of larotrectinib in adult patients with TRK fusion cancer: An expanded data set.

Published date:
05/13/2020
Excerpt:
116 adults (median age: 56 y, range 19–84 y; 53% female) with TRK fusion cancer were treated. Tumor types included thyroid cancer (22%), salivary gland cancer (19%), soft tissue sarcoma (16%), lung cancer (12%), colon cancer (7%), melanoma (5%), breast cancer (5%), GIST (3%), and 9 other types (≤2% each). NTRK fusions involved NTRK1 (43%), NTRK2 (3%), and NTRK3 (54%)....larotrectinib demonstrated robust and durable tumor-agnostic efficacy and favorable safety, supporting NTRK gene fusion testing in patients with solid tumors of any type.
DOI:
10.1200/JCO.2020.38.15_suppl.3610