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Association details:
Biomarker:
NTRK1 fusion
Cancer:
Colon Cancer
Drug:
KRC-108
(
TrkA receptor inhibitor
,
c-MET inhibitor
,
FLT3 inhibitor
,
Aurora kinase A inhibitor
,
RON inhibitor
)
Direction:
Sensitive
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Source:
Biomol Ther (Seoul)
Title:
Characterization of KRC-108 as a TrkA Kinase Inhibitor with Anti-Tumor Effects
Published date:
03/10/2022
Excerpt:
KRC-108...suppressed the growth of KM12C colon cancer cells harboring an NTRK1 gene fusion.
DOI:
10.4062/biomolther.2021.195
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