^
Association details:
| Biomarker: | NT5C2 R367Q |
|---|---|
| Cancer: | T Acute Lymphoblastic Leukemia |
| Drug: | mercaptopurine (DNA synthesis inhibitor, PRPP amidotransferase inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Mechanisms and therapeutic targeting of NT5C2 mutations in relapsed acute lymphoblastic leukemia
Excerpt:
...we developed a murine NOTCH1-driven T-ALL with conditional knock-in of the Nt5c2R367Q mutation, the most recurrent mutation found in relapsed ALL...we confirmed that Nt5c2+/R367Q lymphoblasts show increased resistance to 6-MP in vitro and in vivo.
DOI:
https://doi.org/10.7916/d8-y5g9-9573
