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Association details:
| Biomarker: | NT5C2 R238W |
|---|---|
| Cancer: | Leukemia |
| Drug: | Bredinin (mizoribine) (IMPDH inhibitor, Immunosuppressant) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Clonal Evolution Mechanisms and Collateral Sensitivity to Impdh Inhibitor Therapy in Relapsed Lymphoblastic Leukemia
Excerpt:
Similar results-increased resistance to 6-MP...and increased sensitivity to mizoribine- were documented in human ALL cell lines with expression of relapse associated NT5C2 mutations (p.R238W, p.K359Q, p.R367Q and p.D407A)....we verified increased response to mizoribine in relapsed-leukemia derived xenograft cells harboring NT5C2 mutations...
DOI:
10.1182/blood.V130.Suppl_1.2602.2602
