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Association details:
Evidence:
Evidence Level:
Resistant: D – Preclinical
New
Title:

Structure Function Analysis of Drug Resistance Driver Mutations in Acute Lymphoblastic Leukemia

Excerpt:
Furthermore, NT5C2 mutant proteins conferred resistance to 6-mercaptopurine and 6-thioguanine chemotherapy drugs when expressed in ALL lymphoblasts, suggesting NT5C2 is responsible for the inactivation of nucleoside-analog chemotherapy drugs.
DOI:
10.7916/D8S46XQD