^
Association details:
Evidence:
Evidence Level:
Resistant: D – Preclinical
New
Source:
Title:

Clonal Evolution Mechanisms and Collateral Sensitivity to Impdh Inhibitor Therapy in Relapsed Lymphoblastic Leukemia

Excerpt:
Similar results-increased resistance to 6-MP...and increased sensitivity to mizoribine- were documented in human ALL cell lines with expression of relapse associated NT5C2 mutations (p.R238W, p.K359Q, p.R367Q and p.D407A)....we verified increased response to mizoribine in relapsed-leukemia derived xenograft cells harboring NT5C2 mutations...
DOI:
10.1182/blood.V130.Suppl_1.2602.2602