In each case, cell lines with NSD1 disruption were more sensitive to cisplatin than the parental wild-type cell lines...To mimic the loss of NSD1 pharmacologically, we performed a separate experiment in which parental cells were pre-treated with the HMT inhibitor UNC0379, which also rendered the HNSCC cell lines more sensitive to cisplatin with a growth response that was nearly identical to direct NSD1 disruption...In each case, cell lines with NSD1 disruption were more sensitive to cisplatin than the parental wild-type cell lines...To mimic the loss of NSD1 pharmacologically, we performed a separate experiment in which parental cells were pre-treated with the HMT inhibitor UNC0379, which also rendered the HNSCC cell lines more sensitive to cisplatin with a growth response that was nearly identical to direct NSD1 disruption...