^
Association details:
| Biomarker: | NRG3 deletion |
|---|---|
| Cancer: | Colorectal Cancer |
| Regimen: | FOLFOX (leucovorin calcium + oxaliplatin + 5-fluorouracil) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Deletions in metastatic colorectal cancer with chromothripsis
Published date:
12/10/2019
Excerpt:
Four patients (40%) with PFS over 14 months, presented with NRG3 deletion (oncogene) what could possibly decrease proliferation of cancer cells via decreasing epidermal growth factor receptor (EGFR) activation. Longer PFS was associated with deletion of MIR1269, MIR4465, MIR1261 and MIR4490.
DOI:
10.32471/exp-oncology.2312-8852.vol-41-no-4.13841
