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Association details:
| Biomarker: | NRG1 overexpression |
|---|---|
| Cancer: | Esophageal Squamous Cell Carcinoma |
| Drug: | AV-203 (HER3 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
CAN017, a novel anti-HER3 antibody, exerted great potency in mouse avatars of esophageal squamous cell carcinoma with NRG1 as a biomarker
Published date:
04/15/2021
Excerpt:
Furthermore, the efficacy of CAN017 was positively correlated with NRG1 expression and the response rates in cohort 1 were 73% (8/11) versus 0% (0/13) in NRG1 high and low expression models, respectively.
