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    Association details:
    Biomarker:NRF1 expression
    Cancer:Multiple Myeloma
    Drug:bortezomib (Proteasome inhibitor) +
    Viracept (nelfinavir) (AKT inhibitor, Protease inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: C4 – Case Studies
    Source:
    EHA 2020
    Title:

    NELFINAVIR INHIBITS PROTEASOME RE-SYNTHESIS IN MULTIPLE MYELOMA: THE TCF11/NRF1 PATHWAY AS A THERAPEUTIC TARGET

    Published date:
    05/14/2020
    Excerpt:
    ...nelfinavir decreased the levels of Nrf1 (on protein and RNA level) and interfered with Nrf1 processing in multiple myeloma cells...We then confirmed that nelfinavir alone or even in co-treatment with bortezomib decreased the overall proteasomal activity and myeloma cell survival...