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    Association details:
    Biomarker:NRAS wild-type
    Cancer:Rectal Cancer
    Drug:Erbitux (cetuximab) (EGFR inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: A2 - Guideline
    New
    Source:
    NCCN
    Excerpt:
    Rectal cancer: Systemic therapy for advanced or metastatic disease...FOLFOX + Cetuximab (KRAS/NRAS/BRAF WT only)...FOLFIRI + cetuximab (KRAS/NRAS/BRAF WT only)...FOLFIRINOX or mFOLFIRINOX + cetuximab...Irinotecan + cetuximab (KRAS/NRAS/BRAF WT only)
    Secondary therapy:
    FOLFIRI; irinotecan; FOLFIRINOX; FOLFOX
    Evidence Level:
    Sensitive: C2 – Inclusion Criteria
    New
    Source:
    clinicaltrialsregister.eu
    Title:

    Multicenter prospective single-arm study investigating the efficacy and safety of second-line cetuximab plus chemotherapy treatment in initially RAS-mt mCRC patients who converted to RAS-wt at the time of first progression Studio di fase II a singolo braccio di terapia di II linea con cetuximab e chemioterapia in pazienti con carcinoma colorettale metastatico KRAS e NRAS mutato alla diagnosi con assenza di mutazioni di KRAS/NRAS su plasma alla progressione da prima linea

    Excerpt:
    ...- KRAS/NRAS-wt status, tested on ctDNA, at the time of progression after first line treatment- Life expectancy of at least 3 months; • Diagnosi istologica di adenocarcinoma del colon-retto• KRAS/NRAS mutato su biopsia tissutale (tumore primitivo /metastasi) al momento della diagnosi• Evidenza radiologica di progressione di malattia dopo prima linea con chemioterapia e bevacizumab• Malattia misurabile secondo criteri RECIST (RECIST criteria, vers.1.1); • Uomo o donna, età > 18 anni • ECOG Performance Status = 2; • Adeguata funzionalità ematologica, epatica e renale valutata entro 14 giorni dall’inizio del trattamento in studio Adequate bone marrow function (without hematopoietic growth factor or transfusion support within 14 days prior to study enrollment), including:a. ...
    Trial ID:
    2019-001328-36
    Evidence Level:
    Sensitive: C2 – Inclusion Criteria
    New
    Source:
    clinicaltrials.gov
    Title:

    Neoadjuvant Cetuximab + Chemotherapy Combined With Short-course Radiotherapy

    Excerpt:
    ...An ARMS-PCR proven KRAS, NRAS, PI3KCA and BRAF wild type; 3....
    Trial ID:
    NCT04923620