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Association details:
| Biomarker: | NRAS Q61L |
|---|---|
| Cancer: | Melanoma |
| Drug: | RAF709 (BRAF inhibitor, cRAF inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF
Excerpt:
Correspondingly, RAF709 exhibits greater antitumor activity in cell line and tumor xenograft models harboring BRAF or RAS mutations as compared with those that are wild-type….We generated A375 cells expressing p61BRAFV600E in a doxycycline-inducible system, and measured the activity of RAF709...
DOI:
10.1158/0008-5472.CAN-17-2033
