Treatment of a panel of 9 NRAS-mutant human melanoma cell lines with XL888 (Fig. 1) was associated with concentration-dependent decreases in cell growth...The growth inhibitory effects of XL888 were associated with the induction of a G2–M phase cell-cycle arrest (Fig. 2B) and robust levels of apoptosis by 72 hours (Fig. 2C). No colony formation was observed for any of the 4 cell lines following chronic XL888 (Fig. 2D), with complete eradication of all M318 cells being observed at XL888 concentrations as low as 10 nmol/L...