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Association details:
| Biomarker: | NRAS mutation |
|---|---|
| Cancer: | Melanoma |
| Drug: | UNC2025 (FLT3 inhibitor, MERTK inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Inhibition of MERTK Promotes Suppression of Tumor Growth in BRAF Mutant and BRAF Wild-Type Melanoma
Excerpt:
In patient-derived melanoma xenograft models, treatment with UNC2025 blocked or significantly reduced tumor growth....When cultured at higher density, expansion of BRAFmt (G361) and NRASmt (HMCB) cell lines was significantly inhibited by treatment with 100 to 200 nmol/L UNC2025…
DOI:
10.1158/1535-7163.MCT-18-0456
