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Association details:
| Biomarker: | NRAS mutation |
|---|---|
| Cancer: | Melanoma |
| Drug: | CCT241161 (pan-RAF inhibitor, SRC-family kinase (SFK) inhibitor) + CCT196969 (pan-RAF inhibitor, SRC-family kinase (SFK) inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Paradox-Breaking RAF Inhibitors that Also Target SRC Are Effective in Drug-Resistant BRAF Mutant Melanoma
Excerpt:
...CCT196969 and CCT241161 inhibit ERK and SRC and induce tumor regression in a PDX from the resistant tumor....CCT196969 and CCT241161 inhibit rather than activate MEK in NRAS mutant cells (Figure 2C), and they inhibit NRAS mutant cell growth more efficiently than does PLX4720 (Figure 2D).
DOI:
10.1016/j.ccell.2014.11.006
