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Association details:
| Biomarker: | NRAS mutation |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | Koselugo (selumetinib) (MEK inhibitor) + navtemadlin (KRT-232) (MDM2 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Combined MEK/MDM2 inhibition demonstrates antitumor efficacy in TP53 wild-type thyroid and colorectal cancers with MAPK alterations
Published date:
01/24/2022
Excerpt:
The combination was tested in vivo in seven patient-derived xenograft (PDX) models (five colorectal carcinoma and two papillary thyroid carcinoma models) with different KRAS, BRAF, and NRAS mutations. Combination therapy significantly prolonged event-free survival compared with monotherapy in six of seven models tested.
DOI:
10.1038/s41598-022-05193-z
