^
Association details:
| Biomarker: | NRAS G12D |
|---|---|
| Cancer: | Acute Lymphocytic Leukemia |
| Drug: | U0126 (MEK1 inhibitor, MEK2 inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Mutation of Genes Affecting the RAS Pathway Is Common in Childhood Acute Lymphoblastic Leukemia
Excerpt:
...NRAS G12D mutation but is WT for other components of the pathway, was similarly treated and examined for pERK inhibition. There was complete inhibition of pERK by 10 μmol/L U0126 ( Fig. 5A ) and 20 μmol/L PD98059 (data not shown) after both 8 and 24 h of incubation and a cytotoxic effect was seen for both compounds.
DOI:
10.1158/0008-5472.CAN-08-0101
