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Association details:
| Biomarker: | NR1I2 rs3814055 |
|---|---|
| Cancer: | Chronic Myeloid Leukemia |
| Drug: | imatinib (Bcr-abl inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
THE EFFECT OF PREGNANE X RECEPTOR SNP AND TKI TROUGH CONCENTRATION ON CLINIC RESPONSE AND TOXICITY AMONG CHINESE CML PATIENTS.
Published date:
05/17/2018
Excerpt:
Association between imatinib trough concentrations and response was analyzed in patients orally administrated 400mg/day....It was also showed the mutation group of PXR has significant more patients who achieved MMR(p=0.025) and CMR(P=0.022, Fig4).