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Association details:
| Biomarker: | NPY1R underexpression |
|---|---|
| Cancer: | Estrogen Receptor Positive Breast Cancer |
| Drug: | tamoxifen (Estrogen receptor antagonist) |
| Direction: | Resistant |
Evidence:
Source:
Title:
NPY1R exerts inhibitory action on estradiol-stimulated growth and predicts endocrine sensitivity and better survival in ER-positive breast cancer
Published date:
02/04/2022
Excerpt:
NPY1R gene expression was significantly reduced in EDR, TamR, and FulR derivatives of MCF7 (Fig. 4A), T47D (Fig. 4B), and ZR75-1 (Fig. 4C) ER+ BC cell line models compared to the parental cells (p < 0.05, One-way ANOVA, Tukey test). Similarly, NPY1R gene expression was downregulated in TamR, EDR, and FulR MCF7 xenograft tumors compared to parental MCF7 xenografts grown with continued E2 supplementation (p < 0.05, One-way ANOVA, Dunnett’s test) (Fig. 4D).
DOI:
10.1038/s41598-022-05949-7
