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Association details:
| Biomarker: | NPM1 mutation + FLT3-ITD mutation + TET2 mutation + CUX1 mutation |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | ziftomenib (KO-539) (Menin-MLL inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Kura Oncology Presents First Clinical Data for Menin Inhibitor KO-539 at American Society of Hematology Annual Meeting
Published date:
12/05/2020
Excerpt:
Kura Oncology, Inc...announced preliminary clinical data from KOMET-001, an ongoing Phase 1/2A clinical trial...A second NPM1 mutant patient with FLT3-ITD, TET2 and CUX1 co-mutations achieved a morphological leukemia-free state (MLFS) following four prior lines of therapy...
Trial ID:
