Crizotinib-Resistant NPM-ALK Mutants Confer Differential Sensitivity to Unrelated Alk Inhibitors
Excerpt:
While Ba/F3 NA L1196Q are sensitive to both AP26113 and NVP-TAE684, with an IC50 of 9 nmol/L, Ba/F3 NA I1171N are resistant to both drugs, with an IC50 of 329 and 759 nmol/L, respectively.