^
Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
New
Title:

Crizotinib-Resistant NPM-ALK Mutants Confer Differential Sensitivity to Unrelated Alk Inhibitors

Excerpt:
While Ba/F3 NA L1196Q are sensitive to both AP26113 and NVP-TAE684, with an IC50 of 9 nmol/L, Ba/F3 NA I1171N are resistant to both drugs, with an IC50 of 329 and 759 nmol/L, respectively.
DOI:
10.1158/1541-7786.MCR-12-0569