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    Association details:
    Biomarker:NOTCH1 expression
    Cancer:Acute Myelogenous Leukemia
    Drug:dexamethasone (GCR agonist)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    Source:
    ASH 2020
    Title:

    AML Associated Mesenchymal Stroma Cells Support Growth of AML Cells As a Result of Activated Notch Signaling and This Can be Targeted By Dexamethasone

    Published date:
    11/04/2020
    Excerpt:
    ...Dex treatment affected Notch1 expression (52%; p<0.005) and proliferation of leukemia cells (63%; p<0.001)...mice treated with Dex exhibited significantly prolonged survival (73 vs 21 days, p<0.01) and had a lower percentage of blasts (50%, p<0.01) and MSC compared to leukemic mice receiving vehicle treatment. Our data thus identified Dex mediated abrogation of AML-MSC interaction is in part mediated by affecting Notch signaling.
    DOI:
    https://doi.org/10.1182/blood-2020-134177