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    Association details:
    Biomarker:NOTCH1 C478F
    Cancer:Squamous Cell Carcinoma of Head and Neck
    Drug:WNT974 (Wnt signalling pathway inhibitor, PORCN inhibitor)
    Direction:Sensitive
    Evidence:
    Evidence Level:
    Sensitive: D – Preclinical
    New
    Source:
    Proc Natl Acad Sci U S A
    Title:

    Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

    Excerpt:
    Highly enriched Notch1 LoF mutation in LGK974-responsive HNSCC cell lines…(C) Notch1 C478F showed complete reduction of activities compared with the WT in a Notch1 reporter gene assay with or without DLL1 stimulation.
    DOI:
    10.1073/pnas.1314239110