The panel lists capecitabine monotherapy and continuous infusion 5-FU as first-line and second-line treatment options for patients with locally advanced disease (category 2B), and for patients with poor performance status and metastatic disease (category 2B). They are also recommended as options in the adjuvant settings (category 2A for continuous infusion 5-FU and category 2B for capecitabine). Pancreatic Adenocarcinoma….PRINCIPLES OF SYSTEMIC THERAPY….Intermediate PS2….Preferred Regimens...Capecitabine