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Association details:
| Biomarker: | No biomarker |
|---|---|
| Cancer: | Osteosarcoma |
| Drug: | ifosfamide (Bifunctional alkylating agent) + methotrexate (THF dehydrogenase inhibitor, Dihydrofolic acid reductase inhibitor) + etoposide oral (Topoisomerase II inhibitor, DNA inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Published date:
11/20/2020
Excerpt:
Osteosarcoma: Second-line therapy (relapsed/refractory or metastatic disease)…Useful in Certain Circumstances…High-dose methotrexate, etoposide and ifosfamide