Pemetrexed Injection is a folate analog metabolic inhibitor indicated...as a single agent for the maintenance treatment of patients with locally advanced or metastatic, non-squamous NSCLC whose disease has not progressed after four cycles of platinum-based first-line chemotherapy.

For patients with metastatic NSCLC who progress on combination therapy with PD-1/PD-L1 inhibitors/chemotherapy, subsequent therapy with docetaxel (with or without ramucirumab), pemetrexed (non squamous only), or gemcitabine is recommended...

Pemetrexed continuation maintenance therapy is well-tolerated and offers superior OS compared with placebo, further demonstrating that it is an efficacious treatment strategy for patients with advanced nonsquamous NSCLC and good performance status who did not progress during pemetrexed-cisplatin induction therapy.