Avastin is a vascular endothelial growth factor inhibitor indicated for the treatment of:...Unresectable, locally advanced, recurrent or metastatic non-squamous non-small cell lung cancer, in combination with carboplatin and paclitaxel for first-line treatment.

For patients with metastatic nonsquamous NSCLC and PS 0 and 1 who have contradictions to immunotherapy, the panel decided that the following chemotherapy regimens are "useful in certain circumstances" including 1) carboplatin with paclitaxel (or albumin-bound paclitaxel), docetaxel, etoposide, gemcitabine, or pemetrexed; all are category 1; 2) cisplatin with paclitaxel (or albumin-bound paclitaxel), docetaxel, etoposide, gemcitabine, or pemetrexed; all are category 1; 3) bevacizumab with carboplatin and either paclitaxel or pemetrexed; and 4) gemcitabine with either docetaxel or vinorelbine.