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Association details:
Biomarker:No biomarker
Cancer:Gallbladder Cancer
Regimen:GemOx (gemcitabine + oxaliplatin)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: A2 - Guideline
New
Source:
Excerpt:
Neoadjuvant therapy (for gallbladder cancer only)…Other recommended regimens…Gemcitabine + oxaliplatin (category 2B)
Evidence Level:
Sensitive: B - Late Trials
Title:

Modified gemcitabine and oxaliplatin or gemcitabine + cisplatin in unresectable gallbladder cancer: Results of a phase III randomised controlled trial

Published date:
12/01/2019
Excerpt:
Modified gemcitabine and oxaliplatin or gemcitabine + cisplatin in unresectable gallbladder cancer...Median OS in mGemOx was 9 months and 8·3 months in CisGem; p = 0·057 (hazard ratio = 0·78; 95% CI = 0·60-1·02). Restricted mean OS for follow-up limited to 30 months was 11·2 months (95% CI: 9·8–12·6) in mGemOx and 10·4 months (95% CI: 9·1–11·7) in CisGem....Numerically OS was better with mGemOx.
DOI:
doi.org/10.1016/j.ejca.2019.10.004