VEGZELMA is a vascular endothelial growth factor inhibitor indicated for the treatment of...Metastatic colorectal cancer, in combination with intravenous fluorouracil based chemotherapy for first- or second-line treatment...Metastatic colorectal cancer, in combination with fluoropyrimidine irinotecan- or fluoropyrimidine-oxaliplatin-based chemotherapy for second-line treatment in patients who have progressed on a first-line bevacizumab product-containing regimen.