...the panel recommends chemotherapy corresponding to initial therapy for metastatic disease (eg, FOLFIRI, FOLFOX, or CAPEOX chemotherapy alone or with bevacizumab; FOLFIRI or FOLFOX with panitumumab or cetuximab; FOLFIRINOX alone or with bevacizumab)...Colon cancer: SUBSEQUENT THERAPY...Irinotecan + (cetuximab or panitumumab)...Systemic therapy...FOLFIRINOX ± panitumumab or cetuximab