Principles of systemic therapy for relapse or stage IV disease...Subsequent therapy for clear cell histology...Other recommended regimes: Tivozanib (category 1)
First-line treatment for advanced ccRCC...Sunitinib [I, A], pazopanib [I, A] and tivozanib [II, B; ESMO-MCBS v1.1 score: 1] are alternatives to PD-1 inhibitor-based first-line combinations when immune therapy is contraindicated or not available.