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Association details:
Biomarker:No biomarker
Cancer:Bladder Cancer
Drug:Opdivo (nivolumab) (PD1 inhibitor)
Direction:Sensitive
Evidence:
Evidence Level:
Sensitive: A2 - Guideline
Source:
Published date:
10/20/2021
Excerpt:
Bladder cancer: Adjuvant therapy...Other recommended regimens...Nivolumab
Evidence Level:
Sensitive: B - Late Trials
Source:
Title:

Results for patients with muscle-invasive bladder cancer (MIBC) in the CheckMate 274 trial.

Published date:
05/26/2022
Excerpt:
CheckMate 274 is a phase 3, randomized, double-blind trial of adjuvant NIVO vs PBO in high-risk muscle-invasive urothelial carcinoma...Of 709 randomized pts in the trial, 560 had MIBC (NIVO, n = 279; PBO, n = 281). With a minimum follow-up of 11.0 months, a DFS benefit was observed with NIVO vs PBO in these pts, regardless of tumor PD-L1 expression...Improvement in DFS was observed with NIVO over PBO in pts with MIBC after radical resection regardless of tumor PD-L1 expression.
Secondary therapy:
Chemotherapy
DOI:
10.1200/JCO.2022.40.16_suppl.4585
Trial ID: