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Association details:
Evidence:
Evidence Level:
Sensitive: D – Preclinical
Title:

Quinacrine Has Preferential Anticancer Effects on Mesothelioma Cells With Inactivating NF2 Mutations

Published date:
09/21/2021
Excerpt:
...novel artificially-generated pemetrexed-resistant cells were more sensitive to quinacrine. Unexpectedly, we discovered cells with NF2 mutations were very sensitive to quinacrine...quinacrine has repurposing potential for mesothelioma with NF2 mutations or chemotherapy resistance, and as an adjuvant treatment.
DOI:
https://doi.org/10.3389/fphar.2021.750352