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Association details:
| Biomarker: | NF2 expression |
|---|---|
| Cancer: | Ovarian Cancer |
| Drug: | benzesulfonate (PF-562271) (FAK inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Analyses of merlin/NF2 connection to FAK inhibitor responsiveness in serous ovarian cancer
Excerpt:
...we evaluated merlin protein expression in different human ovarian carcinoma cell lines...merlin level was...lowest in cells where PF-271 prevented anchorage-independent cell growth (HEY and OVCAR8)...A dramatic reduction in the number of HEY and OVCAR8 cells was observed at 0.1 μM PF-271 after 72 h (Fig. 1A, p<0.001)...These results show that HEY and OVCAR8 cells are highly sensitive to PF-271-mediated growth inhibition...
DOI:
https://dx.doi.org/10.1016%2Fj.ygyno.2014.04.044
