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Association details:
| Biomarker: | NF2 deletion |
|---|---|
| Cancer: | Mesothelioma |
| Drug: | TY-0584 (TEAD inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
4491 / 16 - TY-0584: A potent, orally available small molecule YAP/TEAD inhibitor, exhibits anti-tumor effects in vitro and in vivo
Published date:
03/15/2023
Excerpt:
TY-0584 had excellent efficacy in the malignant mesothelioma H226 CDX mouse model, which is driven by NF2 deletion mutation.
