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Association details:
| Biomarker: | NF1 R2450X |
|---|---|
| Cancer: | Melanoma |
| Drug: | Zelboraf (vemurafenib) (BRAF inhibitor, BRAF V600E inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
A genome-scale RNA interference screen implicates NF1 loss in resistance to RAF inhibition
Excerpt:
To confirm that NF1 alterations may confer resistance to B-RAF inhibition in human melanoma, we assessed the status of NF1 using whole exome sequencing of tumors from patients who had relapsed during vemurafenib treatment. We identified four patients whose tumors expressed mutant alleles of NF1 (Figure 7A)
DOI:
10.1158/2159-8290.CD-12-0470
