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Association details:
| Biomarker: | NF1 overexpression |
|---|---|
| Cancer: | Colorectal Cancer |
| Drug: | Erbitux (cetuximab) (EGFR inhibitor) |
| Direction: | Sensitive |
Evidence:
Source:
Title:
Molecular characteristics and clinical outcomes of patients with Neurofibromin 1-altered metastatic colorectal cancer
Published date:
11/02/2021
Excerpt:
In addition, NF1 expression levels were tested for associations with clinical outcomes using data from 431 patients in the CALGB/SWOG 80405 trial...high NF1 expression was associated with better efficacy of cetuximab than bevacizumab.
DOI:
10.1038/s41388-021-02074-z
Trial ID:
