^
Association details:
| Biomarker: | NF1 deletion |
|---|---|
| Cancer: | Acute Myelogenous Leukemia |
| Drug: | mirdametinib (PD-0325901) (MEK inhibitor) |
| Direction: | Resistant |
Evidence:
Source:
Title:
Response and Resistance to MEK Inhibition in Leukaemias Initiated by Hyperactive Ras
Excerpt:
We also tested two other Nf1-deficient AMLs for response to PD0325901. AML #7723 was less sensitive to MEK inhibition in methylcellulose cultures and administering PD0325901 to recipient mice neither prolonged survival nor changed the IC50 for blast colony formation.
DOI:
10.1038/nature08279
